Research proposal on anticancer drugs

  • The overall goal of this proposal is to evaluate a new anticancer

    Research proposal on anticancer drugs

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    NaE Peretti Foundation | Research Study on Anticancer Drugs

    of today’s anticancer drugs target the dna or proteins in tumor cells, but a new discovery by university of california, berkeley, scientists unveils a whole new set of potential targets: the rna intermediaries between dna and proteins.) the molecular modelling & drug design laboratory (mmddlab) at unimorethe molecular modelling & drug design laboratory (mmddlab) at the university of modena and reggio emilia (unimore) has several years' experience in the structure-based design and development of potential drugs acting on enzyme targets of pharmaceutical interest.

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  • NaE Peretti Foundation | Research Study on Anticancer Drugs

    Proposal to Support a Cancer Research PhD Programme in the

    Proposal to Support a Cancer Research PhD Programme in the

    therefore, allosteric ligands are expected to have fewer side effects and higher potency on cancer cells resistant to commonly used drugs.) the collaboratorsthe present research proposal is based on a tight collaboration between the research groups of prof rastelli (unimore), dr.

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  • Research proposal on anticancer drugs

    New target for anticancer drugs: RNA | Research UC Berkeley

    New target for anticancer drugs: RNA | Research UC Berkeley

    study on anticancer drugs targeting the cdk2 and efgr proteinsproject location: italy, modena. for the present proposal, mmddlab has already performed a virtual screening of a huge database of compounds (more than 600.

    Development of novel metal-based anti-cancer chemotherapeutics

    end date: september 2015project number: 2013-025beneficiary: università di modena e reggio emiliathe goal of this project, which received a grant from the nando peretti foundation, is to design and develop anticancer drugs targeting two important proteins, the cdk2 and egfr kinases, by exploiting a promising and hitherto unexplored allosteric type iii mechanism. to their crucial role in the modulation of cell pathways, protein kinases are important targets for anticancer drug discovery.

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  • Anticancer Drug Development

    Research proposal on anticancer drugs

Research proposal on anticancer drugs-The rising cost of anticancer drugs in Australia


Example Proposal (swf)

therefore, the success of this project will open important new ways for obtaining safer and more effective drugs targeting these important anticancer targets. “this new control step, which no one knew about before, could be a great target for new anticancer drugs.

PhD Research Proposal

most scientists have assumed that these mrna molecules are, aside from their unique sequences, generic, with few distinguishing characteristics that could serve as an achilles heel for targeted drugs. for these reasons, the development of drugs with an allosteric mechanism may offer a more effective, less toxic and more clinically amenable therapeutic strategy.

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Example Proposal (swf)
PhD Research Proposal

Research proposal on anticancer drugs

Molecular targets for cancer – EU-funded research projects

“we showed that we could put a damper on invasive growth by manipulating these interactions, so clearly this opens the door to another layer of possible anticancer therapeutics that could target these rna-binding regions,” cate said. he collaborates with several academic and private institutions for the design and discovery of targeted drugs.
“this new control step, which no one knew about before, could be a great target for new anticancer drugs. this project will focus on the rational design, chemical synthesis, and biological and pharmacological evaluation of type iii allosteric ligands with anticancer activity that bind in proximity of helix ac of cdk2 and egfr, two key kinase targets in cancer.

moreover, drugs that target allosteric sites can help circumvent drug resistance, which is another major problem that severely impairs the use of the available anticancer drugs. considering the relevance and timeliness of these goals and standing on the results obtained so far, these investigations have good chances of positioning mmddlab collaborative team at the forefront of anticancer drug discovery on these kinase drug targets.

most scientists have assumed that these mrna molecules are, aside from their unique sequences, generic, with few distinguishing characteristics that could serve as an achilles heel for targeted drugs. goal of this project is to discover potential anticancer drugs targeting cdk2 and egfr via a novel type iii allosteric inhibition mechanism and to optimize their chemical and pharmacological properties for preclinical development.
in the last years particular interest was focused on the design and development of potential anticancer drugs targeting protein kinases. in fact, drug resistance severely limit the efficacy of current drugs on cancer patients.

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